Echoes in Eternity
What We Do in Life ...
Blood  Work - Part Two

by

Reagan Kavanagh



This work of adult fiction, loosely based on characters portrayed by Russell Crowe, includes adult language and experiences; you have been warned.  No copyright infringement on the original work is intended.  Copyright Reagan Kavanagh 2008.

Author’s Note:  We DO know how to spell, but our convention is to spell terms in the way the SPEAKER would spell them based on his or her nationality and educational background.  The exception here is that medical terms, most of which are Latin-based, are generically spelled the same irrespective of nationality of the physician.  RK

 

 

MAXIMUS
“Maximus, Reagan needs you.  It's urgent.”
 
“Emily?”  I heard my daughter's name leave my lips; my throat was suddenly dry, and my voice was hoarse, little more than a whisper.  Terry nodded.
 
“Your paediatrician from Ennis is coming with them …they're on their way to Children's by ambulance.  They'll be there within half-an-hour.  Come on, Mate, I'll drive you.  You don't need to go it alone.”  I nodded and stood, leaving my computer on and my briefcase on the floor beside my desk as I left my office.  Terry spoke to Sooze on our way past her.
 
“Emily's crook, and they're bringing her into Children's.  Let Diana and Dino know, would you?”  Her eyes widened as she nodded, and we walked into the corridor.
 
 
REAGAN
Max's private line had been busy when I called; I called the office line and asked Sooze to put me through to Terry.  I didn't waste time on explanations, telling him only that Emily was ill, and we were on our way to Children's Hospital.  Would he tell Max and have him meet us there?  I closed my phone and looked back at my child.
 
I’d been holding Emily until the paramedics arrived; one of them took her from my arms, cuddling her and talking softly in an effort to soothe her as she screamed.  Drew Spicer and I followed them to the ambulance and once in the bay, the young man placed her on the stretcher for transport.  She was so tiny and looked even more vulnerable now as the paramedic inserted an oxygen line into one nostril and taped it to her tiny face.  She wailed in fear and dismay.  They were monitoring her respiration and heart rate and I watched as the switched her to a pure oxygen feed.  Dr. Spicer reached over and took one of my hands in his; he gave it a squeeze as he looked into my eyes.
 
“Reagan, she's not in extremis, but there's something going on, and we need more care for her than is available at the regional medical center.  Have you called her paediatrician yet?”  I nodded and tried to smile.

“I don't need to call anyone else.  You're with her, and you're her paediatrician now.  Do you have emergency privileges at Children's?”
 
“I have full privileges; we have enough children transferred there to warrant having applied for them years ago.”  He pulled his own phone from his pocket and dialled.
 
“Krista?  It's Drew Spicer from Ennis.  Would you put me through to Dave, please?”  He put his thumb over the microphone as he waited and spoke to me. 
 
“Dave Kinsey …paediatric haematologist.  I've worked with him in the past, and he's excellent.  If it's a blood disorder – and I suspect it is – he'll find it.”  Kinsey must have answered because Spicer spoke into the phone.

“Dave, Drew Spicer here.  I'm inbound to Children’s with an infant …white female, approximately six months of age, history of idiopathic bruising, rash on face and trunk with some evidence on arms and legs, dark malodorous urine, some vomiting …approximately two months duration.  Her mother brought her in again today, and she's now running a temp of 102°.  She's not convulsing, her white count's normal, but her red count is below three million.”  I could hear Dr. Kinsey's voice because Spicer was holding his phone out so I could.
 
“I'll meet you in the ER …what's the mother's name?”
 
“Reagan Kavanagh …father’s name is Max Espan.  He's on his way from his office in Dallas and will meet us there.  Mom's a clinical and forensic psychology professor at SMU; Dad's in risk management.  They're strong people, and you can talk to them as you would to me; Reagan has a background in an allied medical field.”
 
“Got it.  I'm out the door.”  Spicer closed his phone and looked at me.
 
“Let's find out what's wrong with Emily.”
 
 
DREW SPICER
I didn't know what was wrong with Emily Espan, but I sure as Hell intended finding out and as quickly as was feasible.  I had several thoughts, none of them good.  Thalassemia …a genetic disorder commonly found in those of Mediterranean and Asian Indian, South Asian, and Chinese ancestry.  Max Espan was Spanish, of Mediterranean ancestry.  More than two million people in the United States are carriers; most have no idea.  If Emily had thalassemia, she'd be in for blood transfusions every two or three weeks for the rest of her life unless we found a cure.  Thalassemia is another of those genetic disorders for which stem cell research would be a God send.
 
Two months ago I'd considered the possibilities of either aplastic or megaloblastic anaemia and tested for both.  The tests were negative.  I'd considered the possibility of Fifth Disease, a form of parvovirus.  One strain of parvovirus kills canines unless it's rapidly treated, but the form that dogs have isn't zoonotic; it isn’t transmissible to humans.  I'd not tested for Fifth Disease, but Dave Kinsey certainly would.  Any of the various forms of leukaemia was also a possibility, but so far nothing had shown up indicating that.  It was time to call up the heavy artillery, and that's what Kinsey is. 
 
We pulled into the emergency entrance at Children's, and the driver cut the siren.  It was eerily quiet after hearing the noise for so long a time.  There's a rumor that you can't hear the siren if you're inside the ambulance; that's patently incorrect.  Emily had been crying when we loaded her into the ambulance at my office; she'd stopped within five minutes and had remained silent since then, alternately seeming to sleep or to open her huge green-blue eyes to look at her mother who had been leaning forward and over her child for the entire trip.  Reagan would have one Hell of a backache tonight. 
 
The paramedics opened the doors to the back of the ambulance and pulled out the stretcher with Emily on it; Reagan and I followed as they ran for the doors.  I saw Reagan's mouth open as she looked toward the ER’s entrance.  Two men were standing there.  Max Espan was swarthy, with black hair and a beard; the man beside him was fairer, clean shaven, and with chestnut hair.  They looked enough alike to be brothers.  Max spoke as he pulled his wife into his arms.
 
“Cara, ….”  The second man was right behind him.  Reagan spoke into her husband's chest.
 
“Dr. Spicer's called in a paediatric haematologist; I think he's already here.”  He was; I could see Dave Kinsey waiting just inside the door, and I walked toward him with Emily's chart in one hand as the paramedics rolled the tiny child inside.  He nodded to me and held out his hand to the Espans.
 
“Dave Kinsey.”  Max Espan held out his hand in return.
 
“Max Espan; this is my wife Reagan.”  He turned to me – hand out once more – and spoke.
 
“I thank you once more for your care of our child, Dr. Spicer.”  I shook his hand firmly as I spoke.
 
“No need for thanks, Max.  Let's just try and find out what Emily's problem is and see if we can fix it.”  He nodded once, a brief, almost clipped action and turned to the man with him.
 
“Allow me to introduce my colleague, Terry Thorne.  Terry, this is Emily’s paediatrician, Drew Spicer.”  A nod from Thorne, a gesture almost identical to Espan's.  There had to be a blood relationship there somewhere.
 
“You two related?”  Thorne nodded again.
 
“Cousins.  Nice to meet you.”
 
 
TERRY
The bad thing about standing beside Max with people who haven't known us for yonks and seem to have forgotten our resemblance is that one of us always has to come up with an explanation.  We’d finally settled on cousins a while back; that didn't elicit any questions about the difference in surnames.
 
We followed Ems' stretcher straight to the lifts as Kinsey explained he'd pre-admitted her after speaking with Spicer earlier; we were going directly to the paediatric neonatal intensive care unit.  Max could go to Admissions later and sign the requisite paperwork.  My phone rang just as we entered the lift …Diana.  I stepped away from the others to speak quietly to her.
 
“Terry!  Sooze called and said you'd taken Max to the hospital because Reags was bringing Emily in by ambulance!  Is it because of the weird bruises?”
 
“True about the ambulance.  Apparently Ems has been unwell on and off for some time, so it’s a bit more than the bruising.  The paediatrician felt she needed to be at Childrens' for a more thorough evaluation.”
 
“I can be there in an hour.”
 
“Diana, it's likely best you wait.  They're getting admissions sorted and will be ordering more tests.  I'm heading back to the office in a tic.  If you like, take the train in, and we'll drop by here before going home.  Max and Reags have all they can handle just now in dealing with the doctors and nurses.  They wouldn't have time for us – even for comfort – until a bit later.”  She was silent for a tic as she mulled that over.  I have no doubt she’s mentally putting together a food basket for Max and Reags from what we have in the pantry and what she can pick up on the way in.
 
“All right.  I'll see you in a couple of hours.”  I closed my phone just as the doors to the lift opened.
 
“That was Diana.  She's taking the train in, and we'll stop by before going home tonight.  I'll keep Sooze and Dino away until at least tomorrow.”  Reags took a deep breath.
 
“Thanks …we need to concentrate on Emily right now.”
 
“Right.  I'll be going back to the office.  We'll give you a lift back to the car park if you need it tonight.  I know Max has clothes at the loft – we all do – and if necessary, Diana can run down to The Gate early tomorrow and get clothing for you.”  She nodded wearily as Max and I gripped hands, and I gave her a quick hug and kiss on the cheek. 
 
“Call if you need me.”  Max's voice was firm when he spoke.
 
“We shall …and thank you, Terry.”  I was back at my desk within half-an-hour though Sooze, Dino, and I got no work accomplished.  We only managed to frighten ourselves with looking up medical terminology on Web MD and the possible outcomes that fit Ems’ symptoms.
 
 
DAVE KINSEY
I scanned Drew's notes on the Espan child.  He'd done everything possible given the constraints of a small town medical center.  Emily Espan had presented two months previously with low-grade temperature, pallor, moderate anaemia, slight jaundice, idiopathic bruising, and dark urine.  There were no red blood cells in her urine, but that could have changed.  I didn't like the low red blood cell count.  Add to that the facts that the child had been vomiting and had a history of recent infection, and I'd order a complete blood panel, to include testing for thalassemia as the father was of Mediterranean descent.  I'd be looking for that as well as any possible form of anaemia and the various leukaemias.  In years past we only looked at African Americans for sickle-cell disease, but with genetic drift, we now looked at everyone as being a potential carrier or possibly having the disease.
 
The mother had given her child baby Tylenol for temperature regulation during the infection a few months past.  Based on that, I'd also be looking for Fifth Disease; you don't see it often – or at least don’t recognize it as that - but it was possible.  We'd do a complete body scan for any signs of tumour.  Again, you don't often find cancer in a child this young, but it does happen.  We needed to find out what was wrong with this child, and do it fast.  Thank God the parents didn't seem to be the hysterical type as is often the case with very young, first-time parents.  This couple was in their forties, and this was their only child.  They might not display overt indicators of hysteria, but it was obvious they were worried sick for their daughter.
 
We got Baby Espan into the NICU and into a crib; one of the nurses pulled the screens around us, and I turned to the parents.  A quick glance said they could afford the fare, even if it had to come from their own pockets rather than being completely covered by insurance.
 
“I'd suggest we line up round-the-clock, private duty nurses for your daughter.  We don't know what's wrong, and I want her observed constantly.  Twelve hours in this place will have both of you at the breaking point from exhaustion.”  Mr. Espan nodded once.
 
“Do whatever you deem most appropriate for our daughter's care, Doctor.  Her care is all that is important.”  I turned toward the door, speaking as I walked.
 
“I'll write the orders.”
 
*
 
An hour later we'd drawn all the blood samples and taken urine specimens; they were on their way to the lab with STAT labels on everything.  Emily Espan was scheduled in diagnostic radiology in half-an-hour; I'd already administered the sedative that would keep her still and quiet during the MRI.  I'd also ordered full-body x-rays and a spinal tap for tomorrow morning.  Drew Spicer hadn't been able to appreciate any fractures – nor had I on examination – but I'd rather be sure.  We could be looking at osteogenesis imperfecta, commonly known as fragile bone syndrome, and I don't like surprises.  Unexplained bruising is very common in such infants.  Further, if she did have osteogenesis imperfecta, we could do one Hell of a lot of damage just in our various examinations of her.  I’d seen that happen more than once.
 
I walked with Drew and the Espans as Emily's stretcher was rolled to the radiology lab, watched as the infant was transferred to the table that would slide into the MRI, and then settled in with the other three to watch as the MRI proceeded.  An hour later we had the images; no tumours, no soft tissue pathology of any sort that was discernible.  Her spleen was a bit enlarged, but that was common with an infectious process and, thus, unremarkable.  We were still waiting on some of the blood work.  The results on the test for Fifth Disease wouldn't be ready until sometime tomorrow because it takes longer to look for antibodies than for red or white blood cells.  STAT orders not withstanding, some tests just take time. 
 
 
REAGAN
Dave Kinsey and Drew Spicer walked into the NICU just after seven that evening.  Terry and Dee were in the waiting room; policy wouldn't allow any other than parents or siblings over the age of six into the unit. 
 
“Reagan, Emily's under constant observation; Dave and I need to talk to you in the family waiting area.”  I felt my heart sink, and my gut clenched into a hard, tight ball.  I could tell from the look on Max's face when he took my hand that his reaction was the same.  We nodded and silently followed them, sitting on the sofa beside Terry and Dee.
 
“These are our dearest friends and our daughter's godparents.  You may speak freely in their presence.”  Drew smiled.
 
“You beat us to the punch, Max.  Okay, so far the tests are negative, but we don't have all of them back, and Emily still has that date for full body x-rays and her appointment with the paediatric neurologist tomorrow.  At this point, we're both leaning toward Fifth Disease.  Dave?  Your turn.”
 
“Drew tells me you indicated that Emily had a cold a while back.  Is that correct, Dr. Kavanagh?”
 
“Yes, she came down with it a week or so after I'd had a really nasty cold …it was the closest I've ever felt to having influenza without actually doing so.”
 
“That's when you gave her the Baby Tylenol?”  I nodded.
 
“Did you notice anything after the cold disappeared?”  He was going somewhere with this line of questioning, but at the moment I'd no idea where that might be.  I shook my head.
 
“No, …wait.  Yes, I did, and so did Max.”  I turned to my husband.  “Remember the night you asked me if I'd slapped her face and how angry I got at your implication?”  He rubbed his cheek in remembrance; it was somewhat amusing now, but at the time I'd been livid with rage and indignation.
 
“Indeed I do.  I went to check on Emily shortly after my wife changed her nappy and noted a red mark on her face.  It looked remarkably like the flush one notes in an individual who has just been slapped.  I called to my wife, and when she entered the nursery, I asked if she had slapped our daughter.  I could not imagine that she would do so but could think of no other explanation.  Her response was to slap me with all her strength.  She took the greatest possible umbrage at my question and its implications.”
 
“Do you recall if both Emily’s cheeks were red?”  Max shook his head.
 
“In truth, I did not look.  I was too busy with my efforts to placate my wife.  In the end we both decided that her temperature from her recent infection had returned.”
 
“Did you notice anything else?”  I thought for a moment then nodded.
 
“Several days later there was a rash all over her body.  Over the next few days, it took on a lacy pattern.  Emily was scratching at it, I put calamine lotion on it, and she stopped.  It went away a few days later.”  The doctors looked at each other and nodded, and Drew Spicer spoke again.
 
“Have you noticed that her face is red again?”  Max and I looked at each other in surprise and shook our heads.
 
“No …it's pretty dimly lit in the unit, and I haven't noticed it.”
 
“Nor have I.”
 
“Both of us have, but we turn on the over-the-bed fluorescent lamp when we check her.  That flush or rash is the primary hallmark of Parvovirus 19, commonly known as Fifth Disease, and Fifth's can cause every symptom Emily has.” 

Max's jaw dropped.
 
Parvovirus?  Is that not a disease of canines?”  He looked at me before the doctors could answer.  “Cassandra, if our child has contracted this malady from one of our dogs in spite of their having been appropriately vaccinated, we must remove them – and find new homes for them – before Emily returns home.”  Dave Kinsey put one hand on Max's arm.
 
“Take it easy, Mr. Espan.  Yes, dogs are highly susceptible to one specific strain of parvovirus, and if not quickly and properly treated, it kills them.  The strain your daughter has – assuming she has the disorder, and we don't have the lab reports back yet – is not transmissible across species nor is the strain that so often kills dogs.  The fatal strain in dogs is very different genetically from the strain that affects humans.  Parvovirus 19 – Fifth Disease – is often mistaken for measles, but it usually doesn't make a child this ill.  Of course we usually see it in older children – five and up – with a better immune system than an infant, and they don't get as sick.  It's probable that your wife contracted the disease accidentally and passed it on to your daughter.  She'd have thought she had a cold and would have drawn the same conclusion when your daughter became ill.”  I finally found my voice.
 
“What are the other symptoms?  Can all of her symptoms be explained by this one disorder?  Why have I never heard of it?  I thought I'd read everything available on diseases and disorders of infants and children, and so has Max!” 
 
“Relax, both of you.  It's actually very common, but as it resembles a cold so closely most parents never take their children to the doctor for it.  By the time the rash appears, the fever accompanying the disease is gone, and parents usually think their child has gotten into something that caused a skin allergy.”  That made sense; I'd noted Emily's rash – we both had – but I'd thought perhaps she was allergic to the laundry detergent I used.  I'd changed detergents, the rash had disappeared, and I'd been content.  Spicer and Kinsey stood, and we joined them.  Terry and Dee hadn't said a word as Kinsey spoke again.
 
“Well, we both think that's the problem.  It accounts for the anaemia, the bruising as a result of the anaemia, the cold-like symptoms, and Emily's malaise.  Let's wait and see if we get the results back before we do the spinal tap tomorrow.  If so, and the test is positive for antibodies, I'll cancel the tap.  I'm not putting an infant through that procedure without a damned good reason.  If we get results early enough, I'll cancel the x-rays, but that won't be uncomfortable for her so if the results are late, we'll go ahead with that just as a safeguard.  Any questions?”  Max looked at me, and I shook my head.
 
“Not at the moment and thank you.”
 
 
TERRY
Fifth Disease.  Parvovirus 19.  Who in bloody hell would think a variation of a disease often fatal to the family dog could make a child so ill?  Diana and I looked at each other, and I shook my head.  She moved toward Reags and put one arm round her.
 
“Honey, do you and Max want to go to the loft and get a few hours sleep?  If you do, Terry and I’ll stay here.  You can be back over here in less than half-an-hour if you’re needed.”  Reags smiled wanly as Max shook his head.
 
“Thank you, but no.  We will remain here.  We have both lost sleep on occasion in the past; it will not harm us to do so this night.”  Reags returned Diana’s hug as she seconded Max’s comment.
 
“Neither of us wants to be more than a minute away from Emily tonight.  Let’s see what tomorrow brings; we may let one of you spell us then.”
 
For all the concern I knew she felt, Diana knew better than to argue with a Mother Tigress, and that’s what Reags was just now. 
 
“OK.  We just wanted you to know that we’re here, and we’ll be here as long as is necessary.”  She turned to me.  “Terry, let’s go to the loft.  We can be here quicker tonight if necessary.  Max and Reags just might get 40 winks if they didn’t feel the need to be civil to us.  They’ll call if we’re needed.”  That finally got a smile from Max.
 
“Thank you for your concern, and we know it is heartfelt.  I will call early tomorrow as I likely will not be in the office until we have spoken with the doctors.”
 
“No wurries, Mate.  Take all the time you need.”  This was one of the occasions on which I could say that and mean it.  It had been eerily quite in the world of K and R for quite a while.  I wondered how long that would last.
 
 
MAXIMUS
My wife and I spent the night in chairs beside Emily’s cot; we were awake when the doctors appeared before seven the next morning.  Both men were smiling as Cassandra and I stood to meet them.
 
“Doctors?  You manner is less serious this day …have you good news?”  Drew Spicer nodded.
 
“Let’s all go get a cup of coffee – you two look as if you could use one – and we’ll bring you up to date."
 
*
 
“That’s it?  That’s what’s caused all the symptoms?  The bruising, the vomiting, the rash?  All of it?”  My wife was as incredulous as I, and we listened as Dr. Kinsey reassured us.
 
“That’s it …Parvovirus B19, commonly known as Fifth Disease.  Roughly 50% of adults have had it at some point in their lives, usually in middle to late childhood.  In older children it presents with a few sniffles, perhaps a low grade temperature for a couple of days, and that’s it.  It’s more noticeable in an infant because of the lack of a competent immune system.  Dr. Kavanagh picked it up from someone – she could have been sneezed on in an elevator because it’s a droplet infection – and passed it on to Emily.  I suspect you’d also test positive for antibodies, Mr. Espan, as you probably have kissed her within the last six months …kissing is one of the ways it’s spread.”  I could not but laugh at his last statement, and my wife joined me.
 
“What is the appropriate treatment?  How soon may we take our daughter home?” 
 
“That’s the easy part.  Her rash is virtually gone, but calamine lotion is a good topical if she seems itchy.  Her temperature is back to normal, and her blood work is stabilizing.  She’s going to be fine.  If Emily had been almost seven years of age rather than seven months, you’d never have known anything was wrong.  I’ll write the discharge order, and you may take her home after lunch …it will take Admissions and Discharge that long to process the notes.”
 
*
 
“That’s it?  She’s fine?”  Diana and Terry were as incredulous as we had been.  The four of us were sitting in the dining room at the hospital waiting for Emily’s final paperwork to be delivered to the nursing station in order that Cassandra and I might take her home.
 
“She is quite fine.  The doctors believe all her symptoms will subside within a week.  Had she been a bit older it is likely we would never have noticed anything was amiss.”
 
 
REAGAN
Emily had slept in her car seat all the way home, waking only when Max plucked her from it as I went to unlock the door.  The dogs greeted us with enthusiasm, and we let them out into the fenced yard.  It was late afternoon – just after five – and approaching the usual time for Emily’s bath and her dinner followed by bedtime at six.  Max raised an eyebrow at me, and I nodded.  He walked down the hall carrying our child; I heard water running a few minutes later.  He was bathing her in the garden tub in our suite.  She loves to splash about in an inch or so of water, and we think it good practice for when we’ll teach her to swim.  He returned with her bundled into her nightgown just as I was spooning her dinner onto a small plate, and popped her into her high chair.
 
We fed our child together, delighting in this most simple of parental tasks and grateful to whatever gods there may be for her safety.  A short time later we stood over her crib as she lay sleeping quietly.  My husband’s voice was low when he spoke.
 
“Welcome home, Emily.”

 
 
This Concludes Blood Work
 
 
NOTES
LT six months Physicians abbreviate everything, i.e., LT = less than
NICU Neonatal Intensive Care Unit.  Technically, the NICU is usually reserved for neonates – infants of no more than 30 days of age.  Exceptions are made on a case-by-case basis depending on severity of symptomology, potential for crisis, and other factors as determined by the attending physician at time of admission.
STAT Latin for status or standing (amongst MANY other definitions), used by the health care profession to indicate immediate attention required.






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